Evaluating the Efficacy of Bilateral Non-Invasive Vagus Nerve Stimulation in Reducing Migraine Symptoms: A Prospective Observational StudyCreators
Vagus NerveMigrainePain Relief
Table of contents:
Abstract:
Background:
Migraine is a prevalent neurological disorder with a significant impact on patients' quality of life.
This study aimed to evaluate the effects of bilateral non-invasive vagus nerve stimulation
(BnVNS) on migraine frequency, pain intensity, mood, stress levels, and quality of life.
Methods:
Twenty participants, stratified by migraine frequency, were included in this pilot feasibility study.
BnVNS therapy was administered over a 6-week period. Data were collected daily on migraine
frequency, pain severity, mood, stress, and quality of life using the Migraine-Specific Quality of
Life (MSQ) questionnaire and additional custom-developed questions assessing daily mood and
stress levels.
Results:
Migraine frequency decreased by 40.35%, pain days were reduced by 27.66%, and pain
intensity decreased by 42.46% (p < 0.001). Despite these improvements, a 9.48% decrease in
reported quality of life was observed, potentially due to external life stressors. Mood (13.89%)
and stress levels (20.29%) showed improvements.
Conclusion:
BnVNS therapy significantly reduced migraine symptoms and improved mood and stress levels.
These promising results justify further research with larger cohorts and longer study durations to
confirm the potential of BnVNS as a long-term treatment for chronic migraines.
