Pulsetto is a wearable device that uses vagus nerve stimulation (VNS) to promote relaxation and reduce stress and anxiety. By targeting the vagus nerve with gentle electrical impulses, Pulsetto can help induce a state of calm, making it easier to fall asleep and stay asleep.
Advantages of Pulsetto:
Stress Reduction: Experience significant relief from daily stress by activating your vagus nerve and shifting your body into a "rest and digest" state.
Improved Sleep: Pulsetto supports restful sleep by calming your nervous system, helping you wake up refreshed and energized.
Enhanced Mental Clarity: By promoting relaxation, Pulsetto aids in sharpening focus and reducing brain fog.
Digestive Health Support: Vagus nerve stimulation positively impacts the gut-brain connection, aiding digestion and reducing bloating.
Chronic Health Support: Pulsetto offers support for individuals managing chronic stress, anxiety, and fatigue, helping to improve their quality of life.
Using Pulsetto is simple and takes just 4 minutes to start feeling the effects. Here's how it works:
Apply a generous amount of gel to your neck or directly onto the electrodes.
Place the device on your neck.
Pair it with the Pulsetto app on your smartphone.
Choose your desired program and start the device through the app.
The device creates a gentle, pleasant vibration or tingling sensation in your neck area. This stimulation helps activate your parasympathetic nervous system, leading to a calmer, less stressed state.
Truvaga Plus is a highly effective handheld transcutaneous cervical vagus nerve stimulation (tcVNS) device renowned for its precision in delivering 5,000Hz electrical pulses at a 25Hz frequency with a maximum output of 60mA. Designed for quick, two-minute sessions, it connects to a mobile app for seamless operation and is built to last up to 30,000 sessions or three years. The device uses a conductivity spray to ensure optimal electrical transmission when placed on the neck, targeting the vagus nerve to restore neuronal communication and stabilize mental responsivity. Key benefits include significant improvements in focus, stress relief, and sleep quality, with users experiencing faster sleep onset and enhanced overall rest. As a versatile tool for managing stress-related psychiatric disorders, it promotes relaxation by activating neurotransmitters and their receptors in the brain. Clinically aligned with parameters similar to FDA-cleared devices like gammaCore, Truvaga Plus operates within the proven 20-100Hz range supported by studies for relieving psychiatric symptoms and boosting mental health. Its portable design makes it ideal for at-home use, with customizable intensity levels and guided sessions to suit individual comfort, ultimately helping reduce anxiety, improve nervous system regulation, and foster a balanced parasympathetic response.
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Nurosym (by Parasym)
Nurosym, developed by Parasym, is an advanced transcutaneous auricular vagus nerve stimulation (taVNS) device that stands out as the most researched non-invasive VNS system on the market. This portable, handheld device delivers patented microcurrent electrical impulses through an earpiece clipped to the tragus of the left ear, specifically targeting the vagus nerve to activate the parasympathetic nervous system. Users can adjust intensity and duration, typically for 30-60 minutes once or twice daily, allowing integration into routines without interruption. Features include a user-friendly design, CE-certification in the EU, and multiple FDA non-significant risk designations, ensuring safety and efficacy. Benefits encompass a wide range of health improvements, such as alleviating depression, anxiety, and insomnia symptoms (with up to 45% mood enhancement and 48% fatigue reduction in trials), boosting heart rate variability (HRV), reducing inflammation markers by ~78%, enhancing sleep quality by 19%, and improving cognitive functions like memory by ~32%. It also shows promise for conditions like long-COVID, fibromyalgia, chronic fatigue, POTS, and autoimmune diseases by restoring autonomic balance. Nurosym works by sending mild impulses to the brainstem, slowing heart rate, promoting digestion, relaxation, and anti-inflammatory effects. Backed by over 30 peer-reviewed studies, including randomized placebo-controlled trials, and collaborations with 60+ research partners, it has delivered over 2 million safe treatment sessions with no serious adverse effects, making it a scientifically validated option for mental, cardiovascular, and inflammatory health support.
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Apollo Neuro
Apollo Neuro is an innovative wearable device that employs low-frequency vibrotactile stimulation to engage the vagus nerve and parasympathetic nervous system, offering a unique non-electrical approach to wellness. Designed as a band for the wrist, ankle, or clipped to clothing, it features seven targeted modes via a user-friendly app (operable in Airplane mode) for relaxation, focus, sleep, social interactions, and performance enhancement. Sessions are adjustable in duration and intensity, with all-day wear capability and battery life ranging from 6 to 20 hours. Benefits include reduced stress and anxiety, improved sleep quality, enhanced mood and emotional resilience, better focus, and overall well-being by calming the nervous system and promoting relaxation. Apollo works by sending gentle, inaudible vibrations to skin touch receptors, influencing somatosensory and emotional regulation pathways linked to the vagus nerve, thereby increasing vagal tone without invasive methods. While not a traditional electrical VNS device, it draws on research into touch therapy and nervous system modulation, with user testimonials highlighting its effectiveness in daily stress management and recovery. Its portable, discreet design allows for seamless integration into activities, making it ideal for those seeking a subtle, science-inspired tool for biohacking stress and boosting parasympathetic activity.
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gammaCore
gammaCore is a pioneering FDA-cleared non-invasive vagus nerve stimulation (nVNS) device specifically engineered for treating and preventing various headache types, including migraine, cluster headache, hemicrania continua (HC), and paroxysmal hemicrania (PH), suitable for users aged 12 and up. This small, handheld, portable device delivers gentle electrical stimulation through the skin on the neck, activating the vagus nerve—a key "superhighway" of the nervous system—to block pain signals and provide relief. Features include versatile acute and preventive modes: acute treatment involves a few 2-minute sessions for fast-acting pain reduction, while prevention requires twice-daily applications (morning and night) for fewer headache days. Benefits encompass long-lasting relief from headache severity and frequency, reduced disruption to daily life, and decreased reliance on medications, all without invasive procedures or significant side effects. gammaCore works by transmitting electrical impulses to the vagus nerve, facilitating brain-body communication to interrupt headache pain pathways. Clinically proven through extensive studies, it is the only device validated for HC and PH, with endorsements from outlets like Forbes and Men's Health highlighting its efficacy for safe, effective headache management and overall nervous system support.
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Sensate
Sensate is a pebble-shaped relaxation device that utilizes infrasonic vibrations to indirectly stimulate the vagus nerve and enhance parasympathetic activity, providing a non-invasive approach to stress relief and wellness. Placed on the chest or sternum, it features customizable soundscapes and vibrations synced via the Sensate app, with adjustable session lengths for personalized experiences. Key benefits include reduced self-reported stress and anxiety, improved sleep quality, and elevated overall well-being, helping users achieve a deeper sense of calm and nervous system balance. Sensate works by emitting low-frequency sounds that resonate through the body, turning the chest into a natural chamber to influence vagal tone and promote the "rest and digest" state without direct electrical stimulation. A preliminary study with participants showed significant decreases in stress and anxiety, along with better sleep metrics, underscoring its potential, though larger studies are recommended. Its portable design and guided audio integration make it user-friendly for daily routines, appealing to those seeking a sensory, vibration-based method for relaxation, emotional regulation, and holistic health improvement.
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Xen by Neuvana
Xen by Neuvana is an auricular transcutaneous vagus nerve stimulation (taVNS) device that innovatively resembles earbuds, delivering gentle electrical stimulation to the ear canal at a 25Hz frequency with outputs up to 84mA for hands-free use. App-controlled, it offers six waveforms, five lengths, and six signals for 210 customizable combinations, with sessions syncable to music, ambient sounds, podcasts, or TV for an enjoyable experience lasting up to three hours. Benefits include enhanced sleep quality, focus, stress management, mood improvement in disorders, and overall wellness, with users describing the sensation as pleasantly soothing. Xen works by placing electrodes in the ear canal with a saline conductivity medium, stimulating the vagus nerve to activate brain neurotransmitters and receptors, addressing issues like poor sleep and anxiety. Operating within the clinically effective 20-100Hz range, it draws on studies supporting VNS for stress-related psychiatric conditions, making it a versatile, activity-compatible tool for daily integration and parasympathetic enhancement.
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VeRelief Prime by Hoolest
VeRelief Prime by Hoolest is a compact handheld transcutaneous vagus nerve stimulation (tcVNS) device featuring self-contained operation with five adjustable modes (8Hz, 25Hz, 100Hz constant, and two modulated cycles) controlled by simple buttons, no app requirement. It uses proprietary gel tips for conductivity, targeting the vagus nerve on the neck for quick sessions under two minutes for stress, but longer available. Benefits encompass rapid anxiety and stress relief, improved mood, heart rate reduction, and mental recovery by boosting parasympathetic activity, suitable for multifunctional use like targeting ear, wrist. VeRelief works by delivering electrical pulses to stimulate multiple nerves including vagus, promoting relaxation without phone dependency. Tested in placebo-controlled studies on over 150 participants, it emphasizes drug-free stress solutions, with modes backed by research on nerve stimulation efficacy for calm and well-being.
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Vagustim
Vagustim is the world's first multi-purpose smart non-invasive vagus nerve stimulation device, utilizing biosympathetic frequencies to activate the vagus nerve for comprehensive wellness. App-controlled via Bluetooth, it allows full personalization of intensity and duration (starting at 15 minutes, up to 60 minutes daily), with earsets for easy bilateral stimulation and progress tracking for multiple users. Benefits include promoted clarity, relaxation, calm, reduced stress, better sleep, balanced gut health, and overall harmony in the "rest and digest" system, as reported in user testimonials. Vagustim works by gently stimulating the vagus nerve to support natural unwinding, digestion,and restoring body balance. Backed by over 30 clinical trials, 30 publications, and trusted by 100+ prestigious institutions with a 4.6 rating, it has facilitated over 1,000,000 sessions across 40+ countries for safe, effective relaxation and well-being.
FAQ:
1. What is Non-Invasive Vagus Nerve Stimulation (NIVNS)?
Non-Invasive Vagus Nerve Stimulation refers to a therapeutic approach that uses external devices to stimulate the vagus nerve without requiring surgical implantation. The vagus nerve is a key part of the autonomic nervous system, running from the brain through the neck and into the abdomen, influencing functions like heart rate, digestion, and inflammation. NIVNS devices are typically handheld or wearable and apply stimulation through the skin, often targeting branches of the vagus nerve in the ear (auricular) or neck (cervical). This method is designed to be accessible and can often be self-administered at home.
2. How do NIVNS devices work?
These devices deliver mild electrical impulses through electrodes placed on the skin, such as over the neck or ear, to activate the vagus nerve. The stimulation modulates neural signals, potentially affecting the brain's neurotransmitter release, reducing inflammation via the neuroendocrine-immune axis, and influencing autonomic functions like heart rate variability. Unlike direct nerve attachment, the impulses must pass through skin and tissue, which may make the targeting less precise but still effective for many applications. Sessions usually last from a few minutes to an hour, depending on the protocol, and can be programmed for specific intensities.
3. What conditions can NIVNS help treat?
NIVNS has been explored and, in some cases, approved for various conditions. It is commonly used for acute and preventive treatment of cluster headaches and migraines, where it can block pain signals.
Other applications include drug-resistant epilepsy to reduce seizure frequency, treatment-resistant depression to improve mood, post-stroke rehabilitation to enhance motor recovery when combined with therapy, and conditions involving inflammation such as heart failure or autoimmune disorders.
Emerging research also suggests potential benefits for obesity, chronic pain, and brain disorders like traumatic brain injury.
4. What are the potential benefits of using NIVNS devices?
Users may experience reduced seizure activity in epilepsy, alleviation of depressive symptoms, pain relief from headaches or migraines, improved cardiorespiratory fitness, and decreased inflammation in chronic conditions.
Additional benefits include enhanced neuroprotection, better stroke recovery outcomes when paired with rehabilitation, and overall improvements in quality of life for those with treatment-resistant conditions.
As a non-surgical option, it offers convenience, lower costs compared to invasive alternatives, and the ability for home use with minimal monitoring.
5. Are there any risks or side effects associated with NIVNS?
NIVNS is generally well-tolerated with minimal and self-limited side effects, such as local skin irritation at the stimulation site, mild discomfort, or temporary changes in voice or throat sensation.
Rare but serious risks could include cardiac effects, such as irregular heart rhythms, due to the vagus nerve's connection to the heart, though these are uncommon in controlled use.
Long-term effects are still being studied, and it's not recommended for individuals with certain heart conditions, active implants like pacemakers, or during pregnancy without medical advice.
Always consult a healthcare provider to assess personal risks.
6. Is NIVNS safe?
Yes, clinical studies indicate that NIVNS is safe for most users when used as directed, with a low incidence of adverse events—skin irritation being the most common, affecting about 18% of participants in some trials.
It has been deemed tolerable in research involving various populations, including those with epilepsy, depression, and heart conditions.
However, safety can vary by individual health status, so professional medical evaluation is essential before starting.
7. What is the scientific evidence supporting NIVNS?
Evidence comes from randomized controlled trials, pilot studies, and reviews showing efficacy for approved uses like migraine and cluster headache relief, with significant pain reduction reported.
For epilepsy, studies demonstrate reduced seizure frequency; for depression, improvements in mood scales; and for stroke, enhanced motor gains.
Anti-inflammatory effects have been observed in heart failure and autoimmune conditions.
While promising, some areas like obesity show mixed results, and larger-scale, long-term studies are needed to confirm broader applications.
8. How is NIVNS different from invasive vagus nerve stimulation?
Invasive methods involve surgically implanting a device with electrodes wrapped around the vagus nerve, typically for chronic conditions like epilepsy or depression, requiring ongoing medical management.
NIVNS, in contrast, uses external skin-based stimulation, avoiding surgery, infections, or device complications, making it more accessible and cost-effective.
However, invasive approaches may offer more precise and continuous stimulation, while NIVNS effects might be comparable but lack direct head-to-head comparisons.
9. Who should consider using NIVNS devices?
Individuals with conditions like treatment-resistant migraines, cluster headaches, epilepsy, depression, or post-stroke impairments may benefit, especially if other therapies have failed.
It's suitable for those seeking non-drug options or adjunctive therapy. However, it's not for everyone—people with cardiac arrhythmias, recent surgeries, or certain neurological issues should avoid it without clearance from a doctor. A healthcare professional can determine suitability based on medical history.
10. How are NIVNS devices typically used?
Devices are applied to the skin at designated sites (e.g., ear or neck) for sessions ranging from 5-30 minutes, often 1-3 times daily, depending on the condition.
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