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Pulsetto vs Neuvana Xen Vagus Nerve Stimulator | HRV Benefits, Side Effects, Price & Review

Pulsetto vs Neuvana Xen Vagus Nerve Stimulator | HRV Benefits, Side Effects, Price & Review

Key Takeaways

  • Pulsetto and Neuvana's Xen are two top-of-mind vagus nerve stimulation (VNS) devices designed to enhance heart rate variability (HRV) and overall well-being.
  • Both devices offer the non-invasive transcutaneous method to activate the vagus nerve.
  • Understanding the role of the vagus nerve in HRV is crucial for appreciating how these devices can contribute to health optimization.
  • While they use the same technology, each device has its own set of features, benefits, potential side effects, and varying price points that cater to different user needs and preferences.
  • Real-world user reviews and clinical research are important factors to consider when evaluating the efficacy and value of these biohacking tools.

Pulsetto vs Neuvana's Xen Overview

When it comes to optimizing health and enhancing the body's natural rhythms, VNS and VNS devices are frequently discussed. This technique involves sending gentle electrical impulses to the vagus nerve, which has been shown to improve HRV—a key indicator of stress resilience and autonomic nervous system balance.

Two of the most talked-about devices in this space are our device, Pulsetto, and Neuvana's Xen. They both promise to deliver the benefits of VNS, and while they utilize the same technology and approach, there are nuances that are important to consider before you make a purchasing decision.

Key Features and Quick Specs

Firstly, our Pulsetto device boasts a sleek, neck-worn design that targets the vagus nerve transcutaneously. It offers a range of programs aimed at reducing stress, improving sleep, and enhancing mental clarity. 

Pulsetto vagus nerve stimulation device

The Pulsetto is worn around the neck and stimulates the vagus nerve through the skin.

Neuvana's Xen, on the other hand, opts to stimulate the vagus nerve through the ear via earbuds. Xen pairs with a mobile app that allows users to sync their stimulation sessions with music, adding an auditory dimension to the experience.

The Vagus Nerve: Pivotal Player in HRV and Wellbeing

The vagus nerve is the tenth cranial nerve and is responsible for regulating essential bodily functions by connecting the brain to organs like the heart and lungs.

As a core component of the parasympathetic nervous system, it moderates heart rate, digestion, and mood, which helps the body recover from stress. Furthemore, the vagus nerve plays a role in inflammation control and immune response.

Devices like Pulsetto and Xen were designed to influence the vagus nerve's functions to bring about its beneficial effects, such as improving HRV and reducing stress. 

How These Devices Fit into the Biohacking Scene

Biohackers are all about taking control of one’s own biology to achieve optimal performance, health, and well-being. 

Our device and Xen fit perfectly into this scene as they provide a tangible way to influence the body's internal processes. Whether you're looking to manage stress, improve sleep quality, or just boost your mental acuity, these devices offer a cutting-edge way to biohack your nervous system.

Pulsetto vs. Neuvana's Xen Comparison Table

A quick comparison to help you understand how Pulsetto stacks up against Neuvana's Xen:



Neuvana Xen


- Adjustable stimulation parameters
- Range of stimulation programs
- Different intensity levels

- 3 Modes: Sync, Ambient, Sensation
- Customizable waveforms and sensations
- Saves favorite settings


$269 (special price)


VNS Method

Uses a neckband to stimulate the vagus nerve

Uses specialized earbuds to stimulate the vagus nerve

Battery Life

Needs to be charged once per week

Up to 3 hours of continuous use per charge


- Cost-effective
- Customizable stimulation
- Range of programs

- Comfortable, portable design
- Wireless, Bluetooth connectivity
- Personalized sessions via app


- Requires electrode gel
- Not suitable for extensive movement

- Higher price point
- More complex setup

Head-to-Head Feature Match-Up

  • Stimulation Method: Pulsetto and Xen both utilize the transcutaneous approach to stimulate the vagus nerve. Pulsetto applies stimulation through the skin on the neck, while Xen targets the vagus nerve via specially designed earbuds..
  • Programs and Customization: With our device, you can choose from different modes such as stress, anxiety, sleep, burnout, and pain management based on your specific needs. Xen, on the other hand, can be synchronized with music. 
  • Battery Life: The Xen device lasts for three hours on a single charge, while Pulsetto can be used for a week on just one charge.

Now, let's explore each feature in more detail and understand the benefits and drawbacks that come with each device.

Pros and Cons at a Glance

Before we get into the nitty-gritty, here's a quick overview of the pros and cons of each device:

  • Pulsetto Pros: Longer battery life, multiple pre-set programs, and a broader stimulation area.
  • Pulsetto Cons: May be less discreet due to its neck placement and the regular price is a bit pricier. 
  • Xen Pros: Unique music synchronization feature, highly customizable, and discreet earbuds.
  • Xen Cons: Shorter battery life and requires a mobile app for full functionality.

These high-level pros and cons give you an idea of what to expect, but the true test of a product's worth is in the details and how it aligns with your personal health goals.

Differences between Pulsetto vs. Neuvana's Xen

Now that we've covered the basics, let's dig deeper into the differences between our VNS device and Neuvana's Xen, so you can make an informed decision based on your preferences and needs.

Stimulation Technologies: Around The Neck Vs. Through The Ear

Our approach to the transcutaneous method involves stimulating the vagus nerve directly through the skin on your neck, maximizing the impact on the nerve.

Xen's earbud method, however, targets a branch of the vagus nerve that runs close to the surface of the skin in the ear — an equally effective and more discreet approach.

Battery Life and Charging Options

With our device, you're looking at up to a week of battery life—yes, a week!—which is great if you’re not a fan of constantly charging your gadgets. Xen provides up to three hours, which is still respectable but may require more frequent charging depending on your usage patterns. 

Both devices come with their own charging solutions, so keeping them powered up should be a breeze.

Design and Comfort Considerations

Comfort and design are crucial, especially for something you'll be wearing regularly. Pulsetto's neck design is sleek and modern, but it may not be as inconspicuous as some users would like. Xen opted for the simplicity of earbuds—most people won't even know you're using a VNS device.

When it comes to design, it's not just about looks; it's also about how the device feels during use. You want something that's comfortable for long periods and doesn't cause irritation.

App Connectivity and User Experience

App controls are now a staple among wearables, and both the Xen and Pulsetto have them. While both apps are free, we offer a Premium option that allows you to access exclusive content such as unique meditations.

Pulsetto Side Effects

Like any wellness device, Pulsetto comes with its own set of considerations. While side effects are not common, some users may experience mild discomfort at the site of stimulation, such as a tingling sensation or skin irritation. It's important to follow the instructions carefully and to start with the lowest intensity setting to gauge your comfort level.

It’s also a good idea that if you have pre-existing health conditions, especially related to the heart or nervous system, you should consult with a healthcare professional before starting any form of VNS therapy.

User Safety: Precautions and Advisories

When it comes to user safety, Pulsetto takes it seriously. The device is designed to be non-invasive and user-friendly. However, it's not suitable for everyone. If you're pregnant, have a pacemaker, or suffer from seizures, it's crucial to talk to your doctor before using Pulsetto or any other VNS device. 

It's also advised to avoid using the device while driving or operating heavy machinery, as the relaxation effects may impair your ability to concentrate fully on these tasks.

Managing Expectations: Limitations of Use

While Pulsetto can be a powerful tool for improving HRV and wellbeing, it's not a magic cure-all. Managing expectations is, of course, the key here. 

VNS can be a great complement to other healthy lifestyle choices, such as a balanced diet, regular exercise, and sufficient sleep. Think of it as part of a holistic approach to health, rather than a standalone solution.

Moreover, the effects of VNS can vary from person to person. Some may feel the benefits immediately, while others may notice more subtle changes over time. You will need to be patient and consistent if you want to see results. 

Pulsetto Price

As of this writing, we're offering Pulsetto at a discounted price of $269.00, which also includes a trial of the Premium app. We'll also include a free gel tube with your purchase.

Investment vs. Reward: Evaluating Cost-Benefit

Thinking of a really good reason to justify that price?

Think about the value it could bring to your life. 

If you're someone who struggles with stress or poor sleep, and you've tried other methods with limited success, the price of Pulsetto might be justified by the improvement in your quality of life. Just compare the cost of Pulsetto to the cost of medication or therapy to give you some perspective. 

For many, the ability to potentially reduce stress, improve sleep, and enhance mental clarity without medication is worth the purchase.

Accessories and Long-Term Value

As mentioned earlier, we’ll include the gel you need and a charging cable with your purchase, so everything you need to get started is in the box you’ll receive.

Beyond accessories, it’s also worth noting that our customer service is responsive and helpful, which adds to the overall value of your purchase. If you run into any issues or have questions, you can expect reliable support from us.

Neuvana's Xen: Features, HRV Benefits, Side Effects, Price

Switching gears to Neuvana's Xen, this device brings its own unique features to the table. 

Xen's most notable feature is its ability to sync with music, which can make the VNS experience more enjoyable. The earbuds are discreet and the power generator is highly portable, making the whole set easy to use on the go.

Xen is designed with the goal of not only improving HRV but also enhancing overall mood and wellbeing. By stimulating the vagus nerve through the ear, Xen taps into the body's natural relaxation response and can be a useful tool for those looking to manage anxiety or improve focus.

The Xen’s earbuds and power generator that comes with every purchase. 

Xen Features

Neuvana's Xen boasts a number of impressive features, primarily an innovative way to enable vagus nerve stimulation via earbuds. 

  • Music synchronization for a more immersive experience
  • Customizable stimulation settings
  • Portable and discreet design
  • Rechargeable battery with up to three hours of use

The app connectivity allows you to tailor your sessions to your needs, whether you're looking to relax, focus, or energize.

Innovative Aspects and Technical Advances

Xen's innovative approach to VNS through music synchronization is not just about enjoyment—it's based on the idea that music can enhance the vagus nerve's response, potentially amplifying the benefits of the stimulation. 

This is one of the things that sets Xen apart from other devices on the market.

Plus, Xen's auditory approach is the result of extensive research into the most effective ways to stimulate the vagus nerve non-invasively. This focus on innovation is part of what you're paying for when you decide to go with this device.

Travel-Friendly Attributes

For those who live a busy lifestyle or travel frequently, Xen's compact and discreet design is a huge plus. It can be easily packed in a carry-on or purse, and used in various settings—be it on a flight, in a hotel room, or during a break at work. The flexibility and portability of Xen make it an attractive option for health optimization on the go.

Xen’s HRV Benefits

The heart of Xen's value proposition lies in its HRV benefits. By regularly using the device, you may experience:

  • Improved stress management
  • Better sleep quality
  • Enhanced mood and focus

These benefits are linked to a more balanced autonomic nervous system and can have far-reaching effects on your overall health and wellbeing.

Clinical Research Supporting HRV Claims

Neuvana's Xen isn't just based on anecdotal evidence; there's clinical research to back up its claims. Studies have shown that VNS can indeed improve HRV and, by extension, a range of health outcomes. 

Potential Side Effects

While the Neuvana Xen device is generally well-received, some users may experience side effects similar to those of other VNS devices. These can include mild discomfort in the ear, a tickling sensation during stimulation, or skin irritation. 

As with Pulsetto, starting with a lower intensity can help mitigate these effects.

Contraindications and User Feedback

Neuvana's Xen, much like Pulsetto, should be used with caution by individuals with certain medical conditions. The company advises against use by those with cardiac pacemakers, defibrillators, or other implanted electronic devices. Pregnant women and individuals with epilepsy should also refrain from using Xen without medical advice.

How to Mitigate Unwanted Reactions

If you experience any unwanted reactions while using Xen, it's recommended to stop the session immediately and consult with a healthcare provider. Additionally, ensuring that the earbuds are clean and properly positioned can help prevent irritation.

Xen’s Price

Neuvana's Xen currently retails at $459 and includes the power generator, the earbuds, a protective sleeve, and a travel case. 

Comparing Pricing Tiers and Package Deals

Neuvana offers various pricing tiers and package deals for Xen, which can include additional accessories or extended warranties. It's a good idea to check their website for current promotions that could add value to your purchase.

Warranty and Customer Support Services

Neuvana's Xen comes with a 12-month warranty that covers defects in materials and workmanship, which speaks to the company's confidence in their product. 

Customer Reviews and Testimony

Customer reviews and testimonials offer valuable insight into the real-world effectiveness of VNS devices. Let's see what users have to say about Pulsetto and Neuvana's Xen.

Pulsetto Review

Users of Pulsetto often praise the device for its ease of use and the noticeable impact it has on their stress levels and sleep quality. Many report feeling a sense of calmness and improved focus after regular use. 

Highlighting Notable User Success Stories

One user shared a story of how Pulsetto helped them manage anxiety and insomnia, which had been a struggle for years. After consistent use, they noticed a significant improvement in their ability to relax and a more restful sleep pattern, leading to better overall daily functioning.

I've used many of the settings and programs in the app, but the one I'm liking the most is the one for relaxation and sleep.

After connecting to the app, there are specific programs for Pain, Sleep, Burnout, Stress, etc. I've enjoyed getting used to this product and the stimulations it provides. I believe that it is helping with stress and pain.

Overall, I would buy it again!

–Heather Chatlos' review for Amazon

Analysis of User Satisfaction Metrics

An analysis of user satisfaction metrics reveals that Pulsetto has a high rate of positive feedback. The majority of users express satisfaction with the product's performance and value, reinforcing the device's reputation as an effective tool for biohacking enthusiasts.

Neuvana's Xen Review

Xen users often highlight the unique feature of music synchronization as a game-changer, making sessions enjoyable and something to look forward to. Its discreetness is also frequently mentioned, allowing users to incorporate VNS into their daily routine without drawing attention.

I have typically listened to music when I get up in the morning so transitioning to using the Neuvana set was seamless. I think one of my favorite parts of using these headphones, and more so something I’ve noticed on the newest set (I was a first-gen adopter) is that it feels like it connects to your brain waves on a level that can’t be replicated with normal headphones.

–Review for the App Store by user “unlimitedfury”

Documenting User Journeys with Xen

Many Xen users document their journeys, sharing how the device has become an integral part of their wellness routine. Reports of improved mood stability, enhanced focus, and better stress management are common among satisfied customers.

Xen’s Reputation in the Biohacking Community

In the biohacking community, Xen has built a solid reputation as a reliable and innovative tool. Its ability to integrate with a personal music library and its portability are often cited as reasons why it stands out in the crowded field of wellness devices.

Investing in Your Health with Pulsetto VNS

Investing in a VNS device like Pulsetto can be a significant step towards achieving better health and wellbeing. By understanding how the device works and aligning its use with your health objectives, you can maximize the benefits of vagus nerve stimulation.

The Long-Term Benefits of Vagus Nerve Stimulation

Regular use of VNS devices like Pulsetto has been associated with a host of long-term benefits, including improved HRV, reduced stress, better sleep, and enhanced mental clarity. These benefits contribute to a more balanced and resilient nervous system, which is crucial for overall health.

Aligning Pulsetto with Your Health Objectives

To get the most out of Pulsetto, it's important to set clear health objectives and use the device as part of a comprehensive wellness plan. Whether you're aiming to reduce anxiety, improve cardiovascular health, or enhance cognitive function, Pulsetto can be a valuable component of your biohacking arsenal.

Frequently Asked Questions (FAQ)

What Are the Expected Outcomes of Regular VNS?

Regular VNS can lead to improved HRV, which is associated with better stress resilience, a stronger immune system, and improved cardiovascular health. It can also help with mood regulation and cognitive function.

Can VNS Devices Like Pulsetto and Xen Help with Sleep?

Yes, many users report that VNS devices help them fall asleep faster and enjoy a more restful sleep. This is likely due to the calming effect VNS has on the nervous system.

Is There a Risk of Overuse with VNS Devices?

While VNS devices are generally safe, it's important to follow the manufacturer's guidelines for use. Improper use may lead to discomfort or irritation, so it's best to use the device as directed.

How Do I Choose Between Pulsetto and Xen?

Consider your lifestyle, preferences, and health goals. If you prefer a device that's discreet and can be used with your favorite songs, Xen might be the right choice. If you're looking for something with a longer battery life and don't mind a neck-worn device, Pulsetto could be the better option.

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Copyright © 2022 Pulsetto. All rights reserved.
Pulsetto does not provide medical advice, diagnosis or treatment.

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