David Sinclair's Longevity Supplement Stack: A Comprehensive Guide
David Sinclair's Longevity Supplement Stack: A Comprehensive Guide
David Sinclair, a renowned expert in aging research, has developed a comprehensive supplement stack aimed at promoting longevity and overall health. His approach combines cutting-edge science with practical applications, offering insights that can benefit anyone interested in healthy aging. Let's dive into the details of DavidSinclair's supplement regimen and explore how you can apply these principles to your own life.
At the core of David Sinclair's longevity strategy is a carefully selected group of supplements. These include:
Nicotinamide Mononucleotide (NMN): 1 gram daily
Resveratrol: 1 gram daily
Metformin: 800 mg in the evening
Vitamin D3: 4,000-5,000 IU daily
Vitamin K2: 180-360 mcg daily
Low-dose aspirin: 83 mg daily
Spermidine: 1 mg daily
Fisetin: 500 mg daily
Each of these supplements plays a specific role in Sinclair's anti-aging protocol. Let's break down why he includes them and how they might benefit your health.
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One 60g gel tube (can be used up to a month), USB-C charging cable, user guide included
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$278/$478
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
Rated 4.5/5 by 20,137+ Customers
Pulsetto vagus nerve stimulator: feel calmer and sleep better in just 4 minutes a day
Experience immediate relaxation with the Pulsetto vagus nerve stimulator.
Sit back, close your eyes, and immerse yourself in the soothing Pulsetto experience, designed to gently promote a state of calmness and well-being.
Best Value Deal! Save $250!
FREE WORLDWIDE SHIPPING
Select device:
Pulsetto Lite vs Pulsetto FIT
Which one is right for you?
Pulsetto dual-technology, hands-free device
Best if you wear size S or smaller tops. Only with FIT
New stimulation that rises and falls, which feels more fun (coming July–Aug 2025). Only with FIT
20% longer battery life for fewer recharges. Only with FIT
Free lifetime Pulsetto App with 5 expert-designed programs for Stress, Anxiety, and More.
One 60g gel tube (can be used up to a month), USB-C charging cable, user guide included
Extra gift: Pulsetto Premium 14-day Free Trial. 3 extra stimulations, 11 unique guided meditations, 54 breathing exercises, 1200 positive affirmations, and more.
$296/$546
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
$296/$546
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
David Sinclair's Longevity Supplement Stack: A Comprehensive Guide
NMN: The NAD+ Booster
Nicotinamide Mononucleotide (NMN) is a precursor to NAD+, a molecule crucial for cellular energy production and DNA repair. As we age, our NAD+ levels naturally decline, which is why Sinclair takes 1 gram of NMN daily.
Research suggests that boosting NAD+ levels may:
Improve metabolic health
Enhance cognitive function
Support cardiovascular health
While more human studies are needed, the potential benefits of NMN are promising for those looking to support their body's natural aging processes.
Resveratrol: The Sirtuin Activator
Resveratrol, found in small amounts in foods like grapes and berries, is known for its potential to activate sirtuins – proteins that regulate cellular health and longevity. David Sinclair takes 1 gram of resveratrol daily, which is significantly more than what you'd get from diet alone.
Potential benefits of resveratrol include:
Reduced inflammation
Improved cardiovascular health
Enhanced cognitive function
Metformin: The Diabetes Drug with Anti-Aging Potential
Although primarily used to treat type 2 diabetes, metformin has caught the attention of longevity researchers like David Sinclair. He takes 800 mg in the evening as part of his anti-aging regimen.
Some studies suggest metformin may:
Reduce the risk of age-related diseases
Improve insulin sensitivity
Support healthy cellular function
It's important to note that metformin is a prescription medication and should only be taken under medical supervision.
Vitamins D3 and K2: The Dynamic Duo
David Sinclair emphasizes the importance of vitamin D3 and K2 in his supplement stack. These vitamins work synergistically to support:
Bone health
Cardiovascular function
Immune system regulation
He recommends 4,000-5,000 IU of vitamin D3 and 180-360 mcg of vitamin K2 daily.
Low-Dose Aspirin: The Controversial Addition
David Sinclair includes a low dose of aspirin (83 mg) in his daily regimen. While some research suggests potential benefits for heart health and cancer prevention, the use of daily aspirin is controversial and should be discussed with a healthcare provider.
Spermidine and Fisetin: The Newer Additions
More recently, David Sinclair has added spermidine (1 mg) and fisetin (500 mg) to his stack. These compounds are being studied for their potential to:
Promote cellular cleanup (autophagy)
Reduce inflammation
Support cognitive health
Applying David Sinclair's Approach to Your Own Health
While David Sinclair's supplement stack is tailored to his personal needs and based on extensive research, it's not a one-size-fits-all solution. Here are some tips for developing your own longevity-focused supplement routine:
Consult with a healthcare professional: Before starting any new supplement regimen, it's crucial to speak with a doctor or nutritionist who can assess your individual needs.
Start with the basics: Focus on essential nutrients like vitamin D, omega-3 fatty acids, and a high-quality multivitamin before considering more specialized supplements.
Consider your lifestyle: Your diet, exercise habits, and stress levels all play a role in how supplements may affect your body.
Stay informed: Keep up with the latest research on longevity and supplements, but be critical of bold claims and miracle cures.
Monitor your progress: Pay attention to how you feel and consider regular health check-ups to track the effects of your supplement routine.
Beyond Supplements: Holistic Approaches to Longevity
While supplements play a role in David Sinclair's longevity strategy, they're just one piece of the puzzle. Other key factors include:
Diet: David Sinclair follows a plant-based diet with limited animal products and practices intermittent fasting.
Exercise: Regular physical activity is crucial for maintaining health as we age.
Stress management: Techniques like meditation and mindfulness can help reduce the negative impacts of stress on the body.
Sleep: Prioritizing quality sleep is essential for cellular repair and overall health.
Innovative Solutions for Stress Management and Longevity
While supplements and lifestyle changes are important, technology can also play a role in supporting longevity and wellness. One such innovation is the Pulsetto vagus nerve stimulator, which offers a unique approach to stress reduction and overall well-being.
The Pulsetto Vagus Nerve Stimulation Device is a revolutionary tool in non-invasive neuromodulation therapy, designed for wellness enthusiasts and longevity seekers. This lightweight, portable, and user-friendly device integrates seamlessly into modern health routines, empowering you to manage stress, improve sleep, and enhance overall well-being. Pulsetto complements the principles behind David Sinclair’s longevity strategies by offering an innovative, tech-driven approach to health optimization.
Benefits
Stress Reduction: Experience significant relief from daily stress by activating your vagus nerve and shifting your body into a "rest and digest" state.
Improved Sleep: Pulsetto supports restful sleep by calming your nervous system, helping you wake up refreshed and energized.
Enhanced Mental Clarity: By promoting relaxation, Pulsetto aids in sharpening focus and reducing brain fog.
Digestive Health Support: Vagus nerve stimulation positively impacts the gut-brain connection, aiding digestion and reducing bloating.
Chronic Health Support: Pulsetto offers support for individuals managing chronic stress, anxiety, and fatigue, helping to improve their quality of life.
Using Pulsetto is simple and takes just 4 minutes to start feeling the effects. Here's how it works:
Apply a generous amount of gel to your neck.
Place the device on your neck.
Pair it with the Pulsetto app on your smartphone.
Choose your desired program and start the device through the app.
The device creates a gentle, pleasant vibration or tingling sensation in your neck area. This stimulation helps activate your parasympathetic nervous system, leading to a calmer, less stressed state.
As scientists like David Sinclair continue to unravel the mysteries of aging, we can expect to see new developments in the field of longevity. Some areas of ongoing research include:
Senolytic therapies to remove aged cells
Gene therapies to target age-related diseases
Advanced biomarkers to measure biological age more accurately
While these technologies are still in development, they highlight the exciting possibilities for extending healthy lifespans in the future.
Absolutely. The Pulsetto device itself is fully certified by the FCC and CE, which means it complies with strict laws and is approved for use for general health. It uses the lowest bluetooth energy, called “ultra low radiofrequency energy” (ULRE), which is safe for use on the body.
It’s also clinically tested and designed for daily use. Since it’s non-invasive and drug-free, there’s no risk of dependency or side effects. You can use it once a day or several times depending on your needs, before bed, during a stressful moment, or to reset between work tasks. It’s safe, simple, and built for consistency, so the more you use it, the better your nervous system functions over time.
Above all, Pulsetto devices have performed more than 1.5 million simulations already with zero side effects.
How fast will I feel results?
Most users feel noticeably calmer within just 4 minutes. That’s because Pulsetto uses clinically proven vagus nerve stimulation to rapidly shift your nervous system out of fight-or-flight mode and into rest-and-digest. Unlike supplements or meditation apps, there’s no need to wait weeks for subtle changes, relief starts almost immediately. Over time, regular use also strengthens your vagal tone, making you more resilient to stress and better able to stay calm throughout the day.
What does it feel like?
It feels pleasant! Most users describe it as a slight tingling sensation, or a tickle. It’s designed to relax you, so it’s completely pain-free — otherwise it wouldn’t be very calming, would it!
What exactly is the vagus nerve, and why does it matter?
The vagus nerve is the longest cranial nerve in your body, and it plays a crucial role in regulating your mood, stress, digestion, heart rate, and sleep. It’s like your body’s internal switchboard for calm and recovery. Pulsetto gently stimulates this nerve to activate the parasympathetic nervous system, helping you slow down, relax, and restore balance. It’s the same nerve doctors stimulate in clinical settings to treat mood and anxiety disorders, but Pulsetto brings this powerful science home.
Can Pulsetto help me sleep better?
Yes, Pulsetto helps you fall asleep faster, stay asleep longer, and wake up more refreshed. By stimulating your vagus nerve, it activates your parasympathetic nervous system (the one responsible for rest and recovery), helping your body power down naturally. It’s a non-invasive, drug-free solution that works with your body’s own biology. Whether you struggle with racing thoughts, trouble falling asleep, or restless nights, Pulsetto helps create the calm, balanced state your body needs to enter deep, restorative sleep.
What’s included in the Pulsetto App? Is it free?
Yes, the app is 100% free and comes included with the Pulsetto device. It offers 5 unlimited stimulation programs for sleep improvement, nervousness, stress reduction, burnout, and pain management.
The app works with both iOS and Android. It also has a specialized Sound Library filled with sounds specifically designed for Pulsetto, which improve the overall experience.
Do I need to be tech-savvy to use it?
Not at all. Pulsetto is designed to be incredibly easy to use. Just place it around your neck, open the free app, and start your session. The app walks you through everything, from choosing the type of session to adjusting intensity levels. Even if you're not into tech, you’ll find it intuitive and seamless. It’s as easy as putting on a pair of headphones and pressing play, except instead of sound, you're stimulating calm.
Can Pulsetto really help with stress and anxiety?
Yes, and that’s where Pulsetto truly shines. Chronic stress and anxiety are often caused by an overactive sympathetic nervous system (the fight-or-flight response). Pulsetto works by activating the opposite system, the parasympathetic, which signals to your body that it’s safe, helping you relax almost instantly. Whether you're managing daily overwhelm or deeper emotional stress, Pulsetto gives you a powerful tool to self-regulate in a natural, consistent way. It’s peace of mind at the push of a button.
How is Pulsetto different from other wellness tools like meditation apps or supplements?
Meditation apps and supplements can help, but they often take time, focus, and commitment. Pulsetto works physically, not just mentally. By directly stimulating the vagus nerve, it taps into your nervous system’s core functions, creating a fast and reliable physiological shift. You don’t need to “get in the zone” or wait weeks for effects. It’s consistent, clinically supported, and easy to use daily. Pulsetto is not just a wellness tool, it’s a nervous system upgrade.
What if I don’t struggle with anxiety or sleep, can Pulsetto still benefit me?
Yes! Even if you’re not actively struggling, Pulsetto can still improve your overall health and performance. Regular vagus nerve stimulation boosts focus, sharpens mental clarity, supports digestion, reduces inflammation, and even enhances athletic recovery. Think of it like exercise for your nervous system, the more you use it, the stronger and more balanced it becomes. Pulsetto is perfect for anyone who wants to feel more grounded, energized, and resilient in their everyday life.
Who is Pulsetto designed for?
Pulsetto is for anyone who feels overwhelmed, stressed, tired, anxious, or sleep-deprived, basically, most people today. It’s especially helpful for busy professionals, parents, high-performers, and anyone seeking a non-medicated, science-backed way to feel better. Whether you're facing burnout or just want a daily mental reset, Pulsetto empowers you to take back control of your mood, focus, and energy, with just minutes a day.
What if it doesn’t work for me?
We stand behind Pulsetto with a 30-day money-back guarantee and a 2-year warranty. While over 86% of users report feeling calmer and less stressed, we understand that every body is different. That’s why we encourage you to try it risk-free and see how it fits into your routine. If you’re not satisfied, we’ll make it right, because your well-being comes first. No gimmicks, no pressure, just real results or your money back.
Will I have to pay any additional customs, duties or VAT fees when I receive my order?
Depending on your country, it is possible that you will be charged one or more of these fees when you receive your order.
Please note that all international orders are charged in US dollars. International charges are based on the standard exchange rates between your currency and the US dollar at the time of purchase or refund.
Will you notify me by email when my order has shipped?
Yes, we will send an invoice by email when your order has been placed and another when your order has been shipped.
If you can not find our emails in your normal inbox, it is worth checking in your spam or junk mail folder.
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