An In-Depth Analysis of Bryan Johnson's Supplement Stack: Products and Their Purported Benefits
An In-Depth Analysis of Bryan Johnson's Supplement Stack: Products and Their Purported Benefits
Bryan Johnson, the tech millionaire turned "professional biohacker," has made waves in the health and longevity world with his extreme anti-aging protocol. At the heart of his regimen lies an extensive supplement stack, carefully curated to support his quest for optimal health and longevity. Let's dive into Johnson's supplement routine and explore how you might incorporate some of his strategies into your health journey.
The Blueprint: Johnson's Approach to Supplementation
Bryan Johnson's supplement stack is part of his larger "Blueprint" protocol, which includes a strict diet, exercise regimen, and various health interventions. His supplement routine is based on extensive testing and data collection, with adjustments made based on his biomarkers and health outcomes.
The Longevity Mix
At the core of Bryan Johnson's supplement stack is his "Longevity Mix," a blend of compounds designed to support cellular health and combat aging. This mix includes:
Calcium Alpha-Ketoglutarate (Ca-AKG)
Vitamin C
Creatine Monohydrate
Magnesium Citrate
Glucosamine
Glycine
N-Acetyl Cysteine (NAC)
Each of these components plays a specific role in Bryan Johnson's anti-aging strategy. For example, Ca-AKG has shown promise in animal studies for extending lifespan, while creatine supports muscle health and cognitive function.
Essential Soft Gels and Capsules
In addition to the Longevity Mix, Bryan Johnson takes a variety of other supplements in soft gel and capsule form. These include:
Omega-3 fatty acids (EPA/DHA)
Vitamin D3
Vitamin K2
Astaxanthin
Lutein and Zeaxanthin
These supplements are chosen for their potential benefits in supporting heart health, bone strength, eye health, and overall cellular function.
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Pulsetto vagus nerve stimulator: feel calmer and sleep better in just 4 minutes a day
Experience immediate relaxation with the Pulsetto vagus nerve stimulator.
Sit back, close your eyes, and immerse yourself in the soothing Pulsetto experience, designed to gently promote a state of calmness and well-being.
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Pulsetto dual-technology, hands-free device.
Free lifetime Pulsetto App with 5 expert-designed programs for Stress, Anxiety, and More.
One 60g gel tube (can be used up to a month), USB-C charging cable, user guide included
Extra gift: Pulsetto Premium 14-day Free Trial. 3 extra stimulations, 11 unique guided meditations, 54 breathing exercises, 1200 positive affirmations, and more.
$278/$478
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$278/$478
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
Rated 4.5/5 by 20,137+ Customers
Pulsetto vagus nerve stimulator: feel calmer and sleep better in just 4 minutes a day
Experience immediate relaxation with the Pulsetto vagus nerve stimulator.
Sit back, close your eyes, and immerse yourself in the soothing Pulsetto experience, designed to gently promote a state of calmness and well-being.
Best Value Deal! Save $250!
FREE WORLDWIDE SHIPPING
Select device:
Pulsetto Lite vs Pulsetto FIT
Which one is right for you?
Pulsetto dual-technology, hands-free device
Best if you wear size S or smaller tops. Only with FIT
New stimulation that rises and falls, which feels more fun (coming July–Aug 2025). Only with FIT
20% longer battery life for fewer recharges. Only with FIT
Free lifetime Pulsetto App with 5 expert-designed programs for Stress, Anxiety, and More.
One 60g gel tube (can be used up to a month), USB-C charging cable, user guide included
Extra gift: Pulsetto Premium 14-day Free Trial. 3 extra stimulations, 11 unique guided meditations, 54 breathing exercises, 1200 positive affirmations, and more.
$296/$546
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
$296/$546
In Stock: Ships Within 24 Hours (30-Day Money-Back Guarantee)
An In-Depth Analysis of Bryan Johnson's Supplement Stack: Products and Their Purported Benefits
The Role of Technology in Johnson's Protocol
Bryan Johnson's approach to health optimization goes beyond just supplements. He incorporates various technologies to monitor and improve his health. One such device that has gained attention is the Pulsetto Vagus Nerve Stimulation Device.
The Pulsetto Vagus Nerve Stimulation Device represents a groundbreaking leap in neuromodulation therapy, designed to seamlessly integrate into your daily routine. This non-invasive and portable tool empowers users to reduce stress, enhance sleep quality, and boost overall wellness—all while staying aligned with modern trends in health optimization. As a key component of Bryan Johnson's wellness regimen, Pulsetto offers a practical solution for those striving to elevate their self-care practices.
Benefits
Stress Reduction: Experience significant relief from daily stress by activating your vagus nerve and shifting your body into a "rest and digest" state.
Improved Sleep: Pulsetto supports restful sleep by calming your nervous system, helping you wake up refreshed and energized.
Enhanced Mental Clarity: By promoting relaxation, Pulsetto aids in sharpening focus and reducing brain fog.
Digestive Health Support: Vagus nerve stimulation positively impacts the gut-brain connection, aiding digestion and reducing bloating.
Chronic Health Support: Pulsetto offers support for individuals managing chronic stress, anxiety, and fatigue, helping to improve their quality of life.
Using Pulsetto is simple and takes just 4 minutes to start feeling the effects. Here's how it works:
Apply a generous amount of gel to your neck.
Place the device on your neck.
Pair it with the Pulsetto app on your smartphone.
Choose your desired program and start the device through the app.
The device creates a gentle, pleasant vibration or tingling sensation in your neck area. This stimulation helps activate your parasympathetic nervous system, leading to a calmer, less stressed state.
The Science Behind Bryan Johnson's Supplement Choices
While Bryan Johnson's approach is extreme, many of his supplement choices are backed by scientific research. Here's a closer look at some key components:
Omega-3 Fatty Acids
Omega-3s, particularly EPA and DHA, have been extensively studied for their potential benefits in:
Supporting heart health
Reducing inflammation
Promoting brain function
Bryan Johnson takes a high dose of omega-3s daily to support his cardiovascular and cognitive health.
Vitamin D3 and K2
This vitamin duo is crucial for:
Bone health
Immune function
Calcium metabolism
Bryan Johnson's focus on these vitamins reflects the growing understanding of their importance in overall health and longevity.
Creatine Monohydrate
Often associated with athletic performance, creatine has also shown promise in:
Supporting cognitive function
Enhancing muscle health in aging populations
Bryan Johnson's inclusion of creatine in his Longevity Mix aligns with recent research on its potential anti-aging benefits.
Incorporating Bryan Johnson's Strategies into Your Routine
While few of us can replicate Johnson's exact protocol, we can learn from his approach. Here are some tips for optimizing your health routine:
Start with the basics: Focus on a balanced diet, regular exercise, and quality sleep before diving into extensive supplementation.
Get tested: Regular blood work and health assessments can help you identify areas for improvement and guide your supplement choices.
Prioritize key nutrients: Start with well-researched supplements like omega-3s, vitamin D, and magnesium before exploring more experimental options.
Track your progress: Use wearable devices or regular check-ups to monitor how changes in your routine affect your health markers.
The Importance of Personalization
It's crucial to remember that Bryan Johnson's protocol is highly personalized to his specific needs and goals. What works for him may not be appropriate for everyone. Always consult with a healthcare professional before starting any new supplement regimen.
The Role of Stress Management in Longevity
One often overlooked aspect of health optimization is stress management. Chronic stress can negate the benefits of even the most carefully crafted supplement stack. This is where tools like the Pulsetto device come into play.
Why stress management matters:
Chronic stress accelerates aging at the cellular level
High-stress levels can lead to inflammation and various health issues
Effective stress management can improve sleep quality, cognitive function, and overall well-being
By incorporating the Pulsetto Vagus Nerve Stimulator into your routine, you can take a proactive approach to stress management and support your body's natural relaxation response.
Conclusion: Balancing Optimization and Practicality
Bryan Johnson's supplement stack and health protocol offer fascinating insights into the cutting edge of longevity science. While his approach may be extreme for most, we can draw valuable lessons from his dedication to health optimization.
Remember, the key to a successful health routine is consistency and personalization. Start small, focus on the fundamentals, and gradually incorporate new strategies as you learn what works best for your body.
Absolutely. The Pulsetto device itself is fully certified by the FCC and CE, which means it complies with strict laws and is approved for use for general health. It uses the lowest bluetooth energy, called “ultra low radiofrequency energy” (ULRE), which is safe for use on the body.
It’s also clinically tested and designed for daily use. Since it’s non-invasive and drug-free, there’s no risk of dependency or side effects. You can use it once a day or several times depending on your needs, before bed, during a stressful moment, or to reset between work tasks. It’s safe, simple, and built for consistency, so the more you use it, the better your nervous system functions over time.
Above all, Pulsetto devices have performed more than 1.5 million simulations already with zero side effects.
How fast will I feel results?
Most users feel noticeably calmer within just 4 minutes. That’s because Pulsetto uses clinically proven vagus nerve stimulation to rapidly shift your nervous system out of fight-or-flight mode and into rest-and-digest. Unlike supplements or meditation apps, there’s no need to wait weeks for subtle changes, relief starts almost immediately. Over time, regular use also strengthens your vagal tone, making you more resilient to stress and better able to stay calm throughout the day.
What does it feel like?
It feels pleasant! Most users describe it as a slight tingling sensation, or a tickle. It’s designed to relax you, so it’s completely pain-free — otherwise it wouldn’t be very calming, would it!
What exactly is the vagus nerve, and why does it matter?
The vagus nerve is the longest cranial nerve in your body, and it plays a crucial role in regulating your mood, stress, digestion, heart rate, and sleep. It’s like your body’s internal switchboard for calm and recovery. Pulsetto gently stimulates this nerve to activate the parasympathetic nervous system, helping you slow down, relax, and restore balance. It’s the same nerve doctors stimulate in clinical settings to treat mood and anxiety disorders, but Pulsetto brings this powerful science home.
Can Pulsetto help me sleep better?
Yes, Pulsetto helps you fall asleep faster, stay asleep longer, and wake up more refreshed. By stimulating your vagus nerve, it activates your parasympathetic nervous system (the one responsible for rest and recovery), helping your body power down naturally. It’s a non-invasive, drug-free solution that works with your body’s own biology. Whether you struggle with racing thoughts, trouble falling asleep, or restless nights, Pulsetto helps create the calm, balanced state your body needs to enter deep, restorative sleep.
What’s included in the Pulsetto App? Is it free?
Yes, the app is 100% free and comes included with the Pulsetto device. It offers 5 unlimited stimulation programs for sleep improvement, nervousness, stress reduction, burnout, and pain management.
The app works with both iOS and Android. It also has a specialized Sound Library filled with sounds specifically designed for Pulsetto, which improve the overall experience.
Do I need to be tech-savvy to use it?
Not at all. Pulsetto is designed to be incredibly easy to use. Just place it around your neck, open the free app, and start your session. The app walks you through everything, from choosing the type of session to adjusting intensity levels. Even if you're not into tech, you’ll find it intuitive and seamless. It’s as easy as putting on a pair of headphones and pressing play, except instead of sound, you're stimulating calm.
Can Pulsetto really help with stress and anxiety?
Yes, and that’s where Pulsetto truly shines. Chronic stress and anxiety are often caused by an overactive sympathetic nervous system (the fight-or-flight response). Pulsetto works by activating the opposite system, the parasympathetic, which signals to your body that it’s safe, helping you relax almost instantly. Whether you're managing daily overwhelm or deeper emotional stress, Pulsetto gives you a powerful tool to self-regulate in a natural, consistent way. It’s peace of mind at the push of a button.
How is Pulsetto different from other wellness tools like meditation apps or supplements?
Meditation apps and supplements can help, but they often take time, focus, and commitment. Pulsetto works physically, not just mentally. By directly stimulating the vagus nerve, it taps into your nervous system’s core functions, creating a fast and reliable physiological shift. You don’t need to “get in the zone” or wait weeks for effects. It’s consistent, clinically supported, and easy to use daily. Pulsetto is not just a wellness tool, it’s a nervous system upgrade.
What if I don’t struggle with anxiety or sleep, can Pulsetto still benefit me?
Yes! Even if you’re not actively struggling, Pulsetto can still improve your overall health and performance. Regular vagus nerve stimulation boosts focus, sharpens mental clarity, supports digestion, reduces inflammation, and even enhances athletic recovery. Think of it like exercise for your nervous system, the more you use it, the stronger and more balanced it becomes. Pulsetto is perfect for anyone who wants to feel more grounded, energized, and resilient in their everyday life.
Who is Pulsetto designed for?
Pulsetto is for anyone who feels overwhelmed, stressed, tired, anxious, or sleep-deprived, basically, most people today. It’s especially helpful for busy professionals, parents, high-performers, and anyone seeking a non-medicated, science-backed way to feel better. Whether you're facing burnout or just want a daily mental reset, Pulsetto empowers you to take back control of your mood, focus, and energy, with just minutes a day.
What if it doesn’t work for me?
We stand behind Pulsetto with a 30-day money-back guarantee and a 2-year warranty. While over 86% of users report feeling calmer and less stressed, we understand that every body is different. That’s why we encourage you to try it risk-free and see how it fits into your routine. If you’re not satisfied, we’ll make it right, because your well-being comes first. No gimmicks, no pressure, just real results or your money back.
Will I have to pay any additional customs, duties or VAT fees when I receive my order?
Depending on your country, it is possible that you will be charged one or more of these fees when you receive your order.
Please note that all international orders are charged in US dollars. International charges are based on the standard exchange rates between your currency and the US dollar at the time of purchase or refund.
Will you notify me by email when my order has shipped?
Yes, we will send an invoice by email when your order has been placed and another when your order has been shipped.
If you can not find our emails in your normal inbox, it is worth checking in your spam or junk mail folder.
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